C3-PRO is a set of FHIR® compliant software tools and systems that enables integration of biomedical research data collected via ResearchKit and ResearchStack into i2b2 and other databases in a secure, highly scalable fashion.
Source code for all our modules is available on GitHub. We've set up a Google Group for discussions and updates, feel free to stop by and ask questions.
The ecosystem supporting mobile research is expanding, and the list of modules that plug in to C3-PRO is growing. See the architecture overview below to find software modules that suit your needs.
The C3-PRO toolchain is made up of various software modules living in three areas: embedded into your mobile app, server-side pieces that live openly on the www, and modules living behind a firewall, with access to your backend.
Since data exchange happens via FHIR Resources (or encrypted versions thereof), you can easily substitute each component with your own solution. You may also just use parts of the toolchain. Our mobile frameworks for example greatly simplify working with ResearchKit and ResearchStack.
The diagram above illustrates the traditional data flow in a C3-PRO environment. On the mobile side, the iOS and Android mobile frameworks facilitate working with ResearchKit and ResearchStack, respectively, sending encrypted data to (and retrieving data from) the receiver server living on the open web. Secure systems, capable of decrypting incoming data, are running behind the institution’s firewall and store data into an i2b2 research backend.
From the list below you can pick the modules that best suit your needs to design a custom data flow.
This framework uses the HAPI 🔥FHIR library and ResearchStack to bring C3-PRO to Android.
This iOS framework allows you to use 🔥FHIR resources directly with ResearchKit.
Serves as point-of-contact with the app and is the only public-facing part of the toolchain.
Daemon that runs in-house, consumes from the “receiver”'s SQS queue and decrypts 🔥FHIR resources.
A 🔥FHIR DSTU-2 compliant cell for i2b2.
NOTICEfile in the software repositories that you use.
Pfiffner PB, Pinyol I, Natter MD, Mandl KD (2016) C3-PRO: Connecting ResearchKit to the Health System Using i2b2 and FHIR. PLoS ONE 11(3): e0152722. doi:10.1371/journal.pone.0152722.